Ubiquitin-protein ligases (E3s) are highly focused proteins that recognize target substrates and attach ubiquitin molecules to them in order to regulate a wide range of their cellular functions in eukaryotes.
E3DB contains a comprehensive collection of available E3 information, which covers the ubiquitination pathways, E3-specific protein features, E3-dependent functions and processes, and E3-related human diseases. E3DB provides such E3-related information through an interactive graphic interface.

A brief statistics

This release (v1.1) of E3DB contains 1271 entries of E3s, whose pathways include:

• Target proteins: 783
• E1 enzymes: 10
• E2 enzymes: 49
• DUB enzymes: 10

Acknowledgement

E3DB is made available by integrating protein data from biological databases and published literature of worldwide researchers. We thank all the contributors to these databases and literature.

Copyright

E3 protein information is collected from published literature, whose copyright is protected by the corresponding publishers and authors.